Format

Send to

Choose Destination
Elife. 2016 Mar 24;5. pii: e14973. doi: 10.7554/eLife.14973.

How drug resistance takes shape.

Author information

1
Center for Functional Cancer Epigenetics and the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States.
2
Department of Medicine, Harvard Medical School, Boston, United States.

Abstract

Mutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present.

KEYWORDS:

acquired drug resistance; biophysics; breast cancer; estrogen receptor alpha; hormone; human; human biology; medicine; selective estrogen receptor modulators; somatic mutation; structural biology

PMID:
27010172
PMCID:
PMC4821798
DOI:
10.7554/eLife.14973
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for eLife Sciences Publications, Ltd Icon for PubMed Central
Loading ...
Support Center