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Sci Rep. 2016 Mar 24;6:23698. doi: 10.1038/srep23698.

Microstructured Thin Film Nitinol for a Neurovascular Flow-Diverter.

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Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, VA 23284, USA.
Division of Mechanical and Automotive Engineering, Kongju National University, Cheonan, Chungnam, 314-701, Republic of Korea.
Center for Rehabilitation Science and Engineering, Virginia Commonwealth University, VA 23298, USA.
Department of Bioengineering, University of Pittsburgh, PA 15261, USA.


A cerebral aneurysm occurs as a result of a weakened blood vessel, which allows blood to flow into a sac or a ballooned section. Recent advancement shows that a new device, 'flow-diverter', can divert blood flow away from the aneurysm sac. People found that a flow-diverter based on thin film nitinol (TFN), works very effectively, however there are no studies proving the mechanical safety in irregular, curved blood vessels. Here, we study the mechanical behaviors and structural safety of a novel microstructured TFN membrane through the computational and experimental studies, which establish the fundamental aspects of stretching and bending mechanics of the structure. The result shows a hyper-elastic behavior of the TFN with a negligible strain change up to 180° in bending and over 500% in radial stretching, which is ideal in the use in neurovascular curved arteries. The simulation determines the optimal joint locations between the TFN and stent frame. In vitro experimental test qualitatively demonstrates the mechanical flexibility of the flow-diverter with multi-modal bending. In vivo micro X-ray and histopathology study demonstrate that the TFN can be conformally deployed in the curved blood vessel of a swine model without any significant complications or abnormalities.

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