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F1000Res. 2016 Mar 16;5. pii: F1000 Faculty Rev-364. doi: 10.12688/f1000research.7595.1. eCollection 2016.

Nanoparticle-Based Antimicrobials: Surface Functionality is Critical.

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1
Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts, 01003, USA.

Abstract

Bacterial infections cause 300 million cases of severe illness each year worldwide. Rapidly accelerating drug resistance further exacerbates this threat to human health. While dispersed (planktonic) bacteria represent a therapeutic challenge, bacterial biofilms present major hurdles for both diagnosis and treatment. Nanoparticles have emerged recently as tools for fighting drug-resistant planktonic bacteria and biofilms. In this review, we present the use of nanoparticles as active antimicrobial agents and drug delivery vehicles for antibacterial therapeutics. We further focus on how surface functionality of nanomaterials can be used to target both planktonic bacteria and biofilms.

KEYWORDS:

Antimicrobials; antibacterial; bacteria; biofilms; nanoparticles

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