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Braz J Med Biol Res. 1989;22(11):1389-92.

Intragastric infection of germfree and conventional mice with Salmonella typhimurium.

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Departamento de BioquĂ­mica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.


The present study investigates the lethality of intragastric Salmonella typhimurium infection of germfree (GF) and conventional (CV, not germfree) mice. The introduction of only 10 viable S. typhimurium into the gastrointestinal tract of GF mice resulted in death of all animals within 8 days of inoculation. In contrast, the 50% lethal dose for CV mice was 4.7 x 10(3) viable organisms. The results demonstrate that resident microbes protect mice from the pathogenic effect of S. typhimurium infection.

[Indexed for MEDLINE]

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