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Liver Int. 2016 Apr;36(4):467-72. doi: 10.1111/liv.13037.

Extrahepatic manifestations of hepatitis E virus.

Author information

1
Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
2
INSERM U1043, IFR-BMT, CHU Purpan, Toulouse, France.
3
Université Paul Sabatier, Toulouse, France.
4
Department of Virology, CHU Purpan, Toulouse, France.
5
Cornwall Gastrointestinal Unit, Royal Cornwall Hospital and European Centre for the Environment and Human Health, University of Exeter Medical School, Truro, UK.

Abstract

Hepatitis E virus can cause acute, fulminant and chronic hepatitis and has been associated with a range of extrahepatic manifestations. Guillain-Barré syndrome, neuralgic amyotrophy and encephalitis are the main neurological manifestations associated with acute and chronic hepatitis E virus infection. Renal injuries have been also reported, including membranoproliferative glomerulonephritis with or without cryoglobulinemia and membranous glomerulonephritis. Acute pancreatitis, haematological disorders and other autoimmune extrahepatic manifestations of hepatitis E virus, such as myocarditis and thyroiditis, have been also reported. In this comprehensive article, we review all published reports describing hepatitis E virus-associated extrahepatic manifestations.

KEYWORDS:

Anaemia; Guillain-Barré syndrome; hepatitis E virus; kidney disease; neuralgic amyotrophy; pancreatitis; thrombocytopenia

PMID:
27005692
DOI:
10.1111/liv.13037
[Indexed for MEDLINE]

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