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Cells. 2016 Mar 8;5(1). pii: E10. doi: 10.3390/cells5010010.

Hypoxia Induced NF-κB.

Author information

1
Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dow street, Dundee DD1 5EH, UK. l.dignazio@dundee.ac.uk.
2
Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dow street, Dundee DD1 5EH, UK. s.rocha@dundee.ac.uk.

Abstract

As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been identified in the process of hypoxia induced NF-κB. In addition, we will discuss the role of NF-κB in the control of the cellular response to hypoxia.

KEYWORDS:

FIH; HIF-1; Hypoxia; IKK; NF-κB; PHDs; TAK; ubiquitin

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