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Trends Genet. 2016 May;32(5):284-294. doi: 10.1016/j.tig.2016.02.005. Epub 2016 Mar 20.

New Insights into the Regulation of Heterochromatin.

Author information

1
Department of Biological Sciences, Columbia University, New York, NY, USA.
2
Department of Biological Sciences, Columbia University, New York, NY, USA. Electronic address: jia@biology.columbia.edu.

Abstract

All living organisms are constantly exposed to stresses from internal biological processes and surrounding environments, which induce many adaptive changes in cellular physiology and gene expression programs. Unexpectedly, constitutive heterochromatin, which is generally associated with the stable maintenance of gene silencing, is also dynamically regulated in response to stimuli. In this review we discuss the mechanism of constitutive heterochromatin assembly, its dynamic nature, and its responses to environmental changes.

KEYWORDS:

constitutive heterochromatin; dynamics; epigenetic adaptation; stress

PMID:
27005444
PMCID:
PMC4842111
DOI:
10.1016/j.tig.2016.02.005
[Indexed for MEDLINE]
Free PMC Article

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