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Obstet Gynecol Sci. 2016 Mar;59(2):157-62. doi: 10.5468/ogs.2016.59.2.157. Epub 2016 Mar 16.

Genetic analysis of ovarian microcystic stromal tumor.

Author information

1
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Women's Cancer Clinic, Yonsei Cancer Center, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Korea.
2
Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Microcystic stromal tumor (MCST) of the ovary is a rare subtype of ovarian tumor first described in 2009. Although high nuclear expression of β-catenin and β-catenin gene (CTNNB1) mutation are related with ovarian MCST, the origin and genetic background of ovarian MCST remain unclear. In this study, two cases of ovarian MCST are presented. Microscopically, the tumors showed a microcystic pattern and regions with lobulated cellular masses with intervening hyalinized, fibrous stroma. Tumor cells of both cases were stained with CD10, vimentin, and Wilms tumor 1. Genetic analysis was performed and β-catenin gene (CTNNB1) mutation in exon 3 was detected in both cases. This is the first report in regards of detecting CTNNB1 mutation in ovarian MCST through the use of pyrosequencing (a novel sequencing technique).

KEYWORDS:

CTNNB1 mutation; Microcystic stromal tumor; Ovary; Pyrosequencing

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