Format

Send to

Choose Destination
World J Gastroenterol. 2016 Mar 21;22(11):3117-26. doi: 10.3748/wjg.v22.i11.3117.

Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer.

Author information

1
Jonathan Landy, Ailsa L Hart, IBD Unit, St Mark's Hospital, Harrow, London HA1 3UJ, United Kingdom.

Abstract

Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer.

KEYWORDS:

Claudin; Crohn’s disease; Pouchitis; Tight junction; Ulcerative colitis

PMID:
27003989
PMCID:
PMC4789987
DOI:
10.3748/wjg.v22.i11.3117
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Baishideng Publishing Group Inc. Icon for PubMed Central
Loading ...
Support Center