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J Nat Sci Biol Med. 2016 Jan-Jun;7(1):10-5. doi: 10.4103/0976-9668.175017.

Challenges and advances in optimizing liver allografts from donation after circulatory death donors.

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Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.


In recent years, there has been a shift in the donor demographics with an increase in donation after circulatory death (DCD). Livers obtained from DCD donors are known to have poorer outcomes when compared to donors after brainstem death and currently only a small proportion of DCD livers are used. This review outlines the recent technological developments in liver DCD donation, including clinical studies using normothermic regional perfusion and extracorporal machine perfusion of livers from DCD donors.


Donors after circulatory death; liver transplantation; machine perfusion; normothermic regional perfusion; organ preservation

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