Format

Send to

Choose Destination
Brain Struct Funct. 2017 Jan;222(1):267-285. doi: 10.1007/s00429-016-1215-z. Epub 2016 Mar 22.

Meta-analytic connectivity modeling of the human superior temporal sulcus.

Author information

1
Neurology Department, Georgetown University Medical Center, 4000 Reservoir Road NW, Building D, Suite 165, Washington, DC, 20057, USA.
2
Neuroscience Department, Georgetown University Medical Center, 3900 Reservoir Road NW, New Research Building, Room WP19, Washington, DC, 20057, USA.
3
Institute for Advanced Study, Technische Universität München, Lichtenbergstraße 2, 85748, Garching bei München, Germany.
4
Neurology Department, Georgetown University Medical Center, 4000 Reservoir Road NW, Building D, Suite 165, Washington, DC, 20057, USA. turkeltp@georgetown.edu.
5
Research Division, MedStar National Rehabilitation Hospital, 102 Irving St NW, Washington, DC, 20010, USA. turkeltp@georgetown.edu.

Abstract

The superior temporal sulcus (STS) is a critical region for multiple neural processes in the human brain Hein and Knight (J Cogn Neurosci 20(12): 2125-2136, 2008). To better understand the multiple functions of the STS it would be useful to know more about its consistent functional coactivations with other brain regions. We used the meta-analytic connectivity modeling technique to determine consistent functional coactivation patterns across experiments and behaviors associated with bilateral anterior, middle, and posterior anatomical STS subregions. Based on prevailing models for the cortical organization of audition and language, we broadly hypothesized that across various behaviors the posterior STS (pSTS) would coactivate with dorsal-stream regions, whereas the anterior STS (aSTS) would coactivate with ventral-stream regions. The results revealed distinct coactivation patterns for each STS subregion, with some overlap in the frontal and temporal areas, and generally similar coactivation patterns for the left and right STS. Quantitative comparison of STS subregion coactivation maps demonstrated that the pSTS coactivated more strongly than other STS subregions in the same hemisphere with dorsal-stream regions, such as the inferior parietal lobule (only left pSTS), homotopic pSTS, precentral gyrus and supplementary motor area. In contrast, the aSTS showed more coactivation with some ventral-stream regions, such as the homotopic anterior temporal cortex and left inferior frontal gyrus, pars orbitalis (only right aSTS). These findings demonstrate consistent coactivation maps across experiments and behaviors for different anatomical STS subregions, which may help future studies consider various STS functions in the broader context of generalized coactivations for individuals with and without neurological disorders.

KEYWORDS:

Coactivation; Connectivity; Dorsal stream; Meta-analytic connectivity modeling; Network; Superior temporal sulcus

PMID:
27003288
DOI:
10.1007/s00429-016-1215-z
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center