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Nanomedicine (Lond). 2016 Mar;11(6):581-95. doi: 10.2217/nnm.15.218. Epub 2016 Mar 22.

Delivery of a drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers.

Author information

1
Department of Radiology & Radiological Sciences, Medical University of South Carolina, 68 President Street, MSC 120/BEB 213, Charleston, SC 29425, USA.
2
Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC 29425, USA.
3
Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA.
4
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA.

Abstract

AIM:

Glioblastoma multiforme is a devastating disease with no curative options due to the difficulty in achieving sufficient quantities of effective chemotherapies into the tumor past the blood-brain barrier. Micelles loaded with temozolomide (TMZ) were designed to increase the delivery of this drug into the brain.

MATERIALS & METHODS:

pH-responsive micelles composed of distearoyl phosphoethanolamine-PEG-2000-amine and N-palmitoyl homocysteine were surface-functionalized with PDGF peptide and Dylight 680 fluorophore.

RESULTS & CONCLUSION:

PDGF-micelles containing TMZ have specific uptake and increased killing in glial cells compared with untargeted micelles. In vivo studies demonstrated selective accumulation of PDGF-micelles containing TMZ in orthotopic gliomas implanted in mice. Targeted micelle-based drug carrier systems hold potential for delivery of a wide variety of hydrophobic drugs thereby reducing its systemic toxicity.

KEYWORDS:

PDGF; glioblastoma; micelle; nanocarrier; temozolomide

PMID:
27003178
PMCID:
PMC5561905
DOI:
10.2217/nnm.15.218
[Indexed for MEDLINE]
Free PMC Article

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