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J Steroid Biochem Mol Biol. 2017 Jan;165(Pt A):114-120. doi: 10.1016/j.jsbmb.2016.03.023. Epub 2016 Mar 18.

The role of glucocorticoid receptors in metabolic syndrome and psychiatric illness.

Author information

1
Corcept Therapeutics, 149 Commonwealth, Menlo Park, CA, United States. Electronic address: Amoraitis@corcept.com.
2
Corcept Therapeutics, 149 Commonwealth, Menlo Park, CA, United States; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, United States.
3
Corcept Therapeutics, 149 Commonwealth, Menlo Park, CA, United States.

Abstract

Glucocorticoids (GCs) are involved in a large number of the physiological changes associated with metabolic syndrome and certain psychiatric illness. Although significance is often given to the concentration of GC, its biological action is determined by the activation of intracellular GC receptors (GR). Genetic polymorphisms of the GR and the large array of GR related cofactors can directly or indirectly affect the pathophysiology and evolution of these conditions. This review will discuss the effects of GR mutations on metabolic syndrome and psychotic depression.

KEYWORDS:

Glucocorticoid receptor; Metabolic syndrome; Polymorphism; Psychiatric disorders

PMID:
27002803
DOI:
10.1016/j.jsbmb.2016.03.023
[Indexed for MEDLINE]
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