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Organogenesis. 2016 Jan 2;12(1):28-32. doi: 10.1080/15476278.2016.1165378. Epub 2016 Mar 22.

The role of endothelial cells on islet function and revascularization after islet transplantation.

Author information

1
a Department of Physiology, Laboratory of Immunology, Tissue Engineering and Transplant , University Center for Health Sciences, University of Guadalajara , Mexico ;
2
b Institute of Sciences for Human Reproduction "Vida" Guadalajara , Mexico.

Abstract

Islet transplantation has become a widely accepted therapeutic option for selected patients with type 1 diabetes mellitus. However, in order to achieve insulin independence a great number of islets are often pooled from 2 to 4 pancreata donors. Mostly, it is due to the massive loss of islets immediately after transplant. The endothelium plays a key role in the function of native islets and during the revascularization process after islet transplantation. However, if a delayed revascularization occurs, even the remaining islets will also undergo to cell death and late graft dysfunction. Therefore, it is essential to understand how the signals are released from endothelial cells, which might regulate both differentiation of pancreatic progenitors and thereby maintenance of the graft function. New strategies to facilitate islet engraftment and a prompt revascularization could be designed to intervene and might lead to improve future results of islet transplantation.

KEYWORDS:

islet transplantation; islets function; revascularization

PMID:
27002241
PMCID:
PMC4882122
DOI:
10.1080/15476278.2016.1165378
[Indexed for MEDLINE]
Free PMC Article

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