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Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4361-6. doi: 10.1002/anie.201600995. Epub 2016 Mar 11.

Accelerated Discovery in Photocatalysis using a Mechanism-Based Screening Method.

Author information

1
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.
2
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany. glorius@uni-muenster.de.

Abstract

Herein, we report a conceptually novel mechanism-based screening approach to accelerate discovery in photocatalysis. In contrast to most screening methods, which consider reactions as discrete entities, this approach instead focuses on a single constituent mechanistic step of a catalytic reaction. Using luminescence spectroscopy to investigate the key quenching step in photocatalytic reactions, an initial screen of 100 compounds led to the discovery of two promising substrate classes. Moreover, a second, more focused screen provided mechanistic insights useful in developing proof-of-concept reactions. Overall, this fast and straightforward approach both facilitated the discovery and aided the development of new light-promoted reactions and suggests that mechanism-based screening strategies could become useful tools in the hunt for new reactivity.

KEYWORDS:

benzotriazoles; luminescence; phenols; photocatalysis; screening

PMID:
27000485
DOI:
10.1002/anie.201600995

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