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J Neurol Sci. 2016 Apr 15;363:153-7. doi: 10.1016/j.jns.2016.02.042. Epub 2016 Feb 20.

Gut microbiota composition and relapse risk in pediatric MS: A pilot study.

Author information

1
University of British Columbia, Vancouver, BC, Canada. Electronic address: helen.tremlett@ubc.ca.
2
University of California, San Francisco, San Francisco, CA, United States.
3
University of Utah, Salt Lake City, UT, United States.

Abstract

We explored the association between baseline gut microbiota (16S rRNA biomarker sequencing of stool samples) in 17 relapsing-remitting pediatric MS cases and risk of relapse over a mean 19.8 months follow-up. From the Kaplan-Meier curve, 25% relapsed within an estimated 166 days from baseline. A shorter time to relapse was associated with Fusobacteria depletion (p=0.001 log-rank test), expansion of the Firmicutes (p=0.003), and presence of the Archaea Euryarchaeota (p=0.037). After covariate adjustments for age and immunomodulatory drug exposure, only absence (vs. presence) of Fusobacteria was associated with relapse risk (hazard ratio=3.2 (95% CI: 1.2-9.0), p=0.024). Further investigation is warranted. Findings could offer new targets to alter the MS disease course.

KEYWORDS:

16S rRNA; Cox regression; Gut microbiota; Kaplan-Meier; Pediatric multiple sclerosis; Relapse risk; Survival analyses

PMID:
27000242
PMCID:
PMC4806409
DOI:
10.1016/j.jns.2016.02.042
[Indexed for MEDLINE]
Free PMC Article

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