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Cell Microbiol. 2016 Jun;18(6):800-6. doi: 10.1111/cmi.12593. Epub 2016 Apr 14.

Post-transcriptional gene regulation in the biology and virulence of Candida albicans.

Author information

1
Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Abstract

In the human fungal pathogen Candida albicans, remodelling of gene expression drives host adaptation and virulence. Recent studies revealed that in addition to transcription, post-transcriptional mRNA control plays important roles in virulence-related pathways. Hyphal morphogenesis, biofilm formation, stress responses, antifungal drug susceptibility and virulence in animal models require post-transcriptional regulators. This includes RNA binding proteins that control mRNA localization, decay and translation, as well as the cytoplasmic mRNA decay pathway. Comprehensive understanding of how modulation of gene expression networks drives C. albicans virulence will necessitate integration of our knowledge on transcriptional and post-transcriptional mRNA control.

PMID:
26999710
PMCID:
PMC5074327
DOI:
10.1111/cmi.12593
[Indexed for MEDLINE]
Free PMC Article

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