Format

Send to

Choose Destination
Pathogens. 2016 Mar 15;5(1). pii: E30. doi: 10.3390/pathogens5010030.

Adhesive Pili in UTI Pathogenesis and Drug Development.

Author information

1
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA. cspaulding@wustl.edu.
2
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA. hultgren@wusm.wustl.edu.
3
Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA. hultgren@wusm.wustl.edu.

Abstract

Urinary tract infections (UTIs) are one of the most common bacterial infections, affecting 150 million people each year worldwide. High recurrence rates and increasing antimicrobial resistance among uropathogens are making it imperative to develop alternative strategies for the treatment and prevention of this common infection. In this Review, we discuss how understanding the: (i) molecular and biophysical basis of host-pathogen interactions; (ii) consequences of the molecular cross-talk at the host pathogen interface in terms of disease progression; and (iii) pathophysiology of UTIs is leading to efforts to translate this knowledge into novel therapeutics to treat and prevent these infections.

KEYWORDS:

CAUTI; Enterococcus; UPEC; UTI; antibiotic-resistance; chaperone-usher pathway (CUP) pili; pili; rUTI; vaccine

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center