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Microb Pathog. 2016 Jun;95:86-94. doi: 10.1016/j.micpath.2016.03.003. Epub 2016 Mar 17.

Chemical composition and in vitro evaluation of antioxidant, antimicrobial, cytotoxicity and anti-acetylcholinesterase properties of Tunisian Origanum majorana L. essential oil.

Author information

1
Laboratory of Transmissible Diseases and Biologically Active Substances, Department of Microbiology, Faculty of Pharmacy, University of Monastir, Avicenne Street, 5000 Monastir, Tunisia. Electronic address: bio.hafedh@gmail.com.
2
Arid Lands Institute, Range Ecology Laboratory, 4119 Medenine, Tunisia.
3
Laboratory of Transmissible Diseases and Biologically Active Substances, Department of Microbiology, Faculty of Pharmacy, University of Monastir, Avicenne Street, 5000 Monastir, Tunisia.
4
Laboratory of Plant Biotechnology, Faculty of Science, University of Sfax, B.P. 1171, 3000, Tunisia.
5
Laboratory of Plant Biotechnology, Faculty of Science, University of Sfax, B.P. 1171, 3000, Tunisia; College of Science and Arts in Baljurashi, Al Baha University, P.O.Box (1988) Al Baha, Saudi Arabia.

Abstract

This study investigated the chemical composition and evaluated the antioxidant, antimicrobial, cytotoxic and anti-acetylcholinesterase properties of Tunisian Origanum majorana essential oil. The findings showed that the oil exhibited high activity, particularly in terms of reducing power and β-Carotene bleaching, inducing higher IC50 values than BHT. The oil showed an important antimicrobial activity against 25 bacterial and fungal strains. In fact, the IZ, MIC and MBC values recorded for the bacterial strains were in the range of 8 ± 0-18.33 ± 0.57 mm, 0.097-3.125 and 0.39-6.25 mg/mL, respectively. The IZ, MIC and MFC values of the fungal strains varied between 11±0-28 ± 0 mm, 0.058-0.468 mg/mL and 0.234-1.875 mg/mL, respectively. A low cytotoxic effect was observed against cancer (Hep-2 and HT29) and continuous cell lineage (Vero), with CC50 values ranging from 13.73 to 85.63 mg/mL. The oil was also evaluated for anti-acetylcholinesterase effects, which showed that it exhibited significant activity with IC50 values reaching 150.33 ± 2.02 μg/mL.

KEYWORDS:

Anti acetylcholinesterase; Antimicrobial; Antioxidant; Cytotoxicity; Essential oil; Origanum majorana

PMID:
26997648
DOI:
10.1016/j.micpath.2016.03.003
[Indexed for MEDLINE]

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