Format

Send to

Choose Destination
Cell. 2016 Mar 24;165(1):180-191. doi: 10.1016/j.cell.2016.01.046. Epub 2016 Mar 17.

Neuronal Firing Rate Homeostasis Is Inhibited by Sleep and Promoted by Wake.

Author information

1
Department of Biology, Brandeis University, Waltham, MA 02454, USA.
2
Department of Biology, Brandeis University, Waltham, MA 02454, USA. Electronic address: turrigiano@brandeis.edu.

Abstract

Homeostatic mechanisms stabilize neural circuit function by keeping firing rates within a set-point range, but whether this process is gated by brain state is unknown. Here, we monitored firing rate homeostasis in individual visual cortical neurons in freely behaving rats as they cycled between sleep and wake states. When neuronal firing rates were perturbed by visual deprivation, they gradually returned to a precise, cell-autonomous set point during periods of active wake, with lengthening of the wake period enhancing firing rate rebound. Unexpectedly, this resetting of neuronal firing was suppressed during sleep. This raises the possibility that memory consolidation or other sleep-dependent processes are vulnerable to interference from homeostatic plasticity mechanisms. PAPERCLIP.

Comment in

PMID:
26997481
PMCID:
PMC4809041
DOI:
10.1016/j.cell.2016.01.046
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center