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J Cell Sci Suppl. 1989;12:145-8.

Control of G2 delay by the rad9 gene of Saccharomyces cerevisiae.

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Department of Genetics, University of Washington, Seattle 98195.


In response to DNA damage, Saccharomyces cerevisiae cells arrest the cell cycle in the G2 phase. Arrest is defective in rad9 mutants; rad9 cells divide and die without repairing the damage. Several cell cycle mutants that are defective in DNA replication arrest in G2 at the restrictive temperature; this arrest is due to the RAD9 control function. Thus RAD9 is responsible for the fact that mitosis is normally dependent upon DNA replication, a function we term a 'checkpoint'. Four additional genes have been identified that are also components of the RAD9 checkpoint.

[Indexed for MEDLINE]

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