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Acta Trop. 2017 Jan;165:100-109. doi: 10.1016/j.actatropica.2016.03.013. Epub 2016 Mar 17.

Geospatial and age-related patterns of Taenia solium taeniasis in the rural health zone of Kimpese, Democratic Republic of Congo.

Author information

1
Institute of Health and Society, Université Catholique de Louvain, Brussels, Belgium; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo. Electronic address: jmadinga@yahoo.fr.
2
Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
3
Zone de santé Rurale de Kimpese, Democratic Republic of the Congo.
4
Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Kinshasa, Democratic Republic of the Congo.
5
Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
6
Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo; Department of Tropical Medicine, University of Kinshasa, Democratic Republic of the Congo.
7
Institute of Health and Society, Université Catholique de Louvain, Brussels, Belgium.
8
Department of Infectious Disease and Epidemiology, Imperial College, London, UK.

Abstract

BACKGROUND:

Taenia solium infections are mostly endemic in less developed countries where poor hygiene conditions and free-range pig management favor their transmission. Knowledge on patterns of infections in both human and pig is crucial to design effective control strategies. The aim of this study was to assess the prevalence, risk factors and spatial distribution of taeniasis in a rural area of the Democratic Republic of Congo (DRC), in the prospect of upcoming control activities.

METHODS:

A cross-sectional study was conducted in 24 villages of the health zone of Kimpese, Bas Congo Province. Individual and household characteristics, including geographical coordinates were recorded. Stool samples were collected from willing participants and analyzed using the copro-antigen enzyme-linked immunosorbent assay (copro-Ag ELISA) for the detection of taeniasis. Blood samples were collected from pigs and analyzed using the B158/B60 monoclonal antibody-based antigen ELISA (sero-Ag ELISA) to detect porcine cysticercosis. Logistic regression and multilevel analysis were applied to identify risk factors. Global clustering and spatial correlation of taeniasis and porcine cysticercosis were assessed using K functions. Local clusters of both infections were identified using the Kulldorff's scan statistic.

RESULTS:

A total of 4751 participants above 5 years of age (median: 23 years; IQR: 11-41) were included. The overall proportion of taeniasis positivity was 23.4% (95% CI: 22.2-24.6), ranging from 1 to 60% between villages, with a significant between-household variance of 2.43 (SE=0.29, p<0.05). Taeniasis was significantly associated with age (p<0.05) and the highest positivity was found in the 5-10 years age group (27.0% (95% CI: 24.4-29.7)). Overall, 45.6% (95% CI: 40.2-51) of sampled pigs were sero-positive. The K functions revealed a significant overall clustering of human and pig infections but no spatial dependence between them. Two significant clusters of taeniasis (p<0.001; n=276 and n=9) and one cluster of porcine cysticercosis (p<0.001; n=24) were found.

CONCLUSION:

This study confirms high endemicity and geographical dispersal of taeniasis in the study area. The role of age in taeniasis patterns and significant spatial clusters of both taeniasis and porcine cysticercosis were evidenced, though no spatial correlation was found between human and pig infections. Urgent control activities are needed for this endemic area.

KEYWORDS:

Democratic republic of Congo; Epidemiology; Porcine cysticercosis; Spatial clustering; Taeniasis

PMID:
26996821
PMCID:
PMC5178865
DOI:
10.1016/j.actatropica.2016.03.013
[Indexed for MEDLINE]
Free PMC Article

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