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Yonsei Med J. 2016 May;57(3):599-605. doi: 10.3349/ymj.2016.57.3.599.

Lymphangiogenesis in Breast Cancer Correlates with Matrix Stiffness on Shear-Wave Elastography.

Author information

1
Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
2
Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
3
Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
4
Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. cho1988@yuhs.ac.

Abstract

PURPOSE:

To correlate tumor stiffness and lymphangiogenesis in breast cancer and to find its clinical implications.

MATERIALS AND METHODS:

A total of 140 breast cancer patients were evaluated. Tumor stiffness was quantitatively measured by shear-wave elastography in preoperative ultrasound examination, calculated as mean elasticity value (kPa). Slides of resected breast cancer specimens were reviewed for most fibrotic area associated with tumor. D2-40 immunohistochemical staining was applied for fibrotic areas to detect the lymphatic spaces. Microlymphatic density, tumor stiffness, and clinicopathologic data were analyzed.

RESULTS:

Higher elasticity value was associated with invasive size of tumor, microlymphatic density, histologic grade 3, absence of extensive intraductal component, presence of axillary lymph node metastasis, and Ki-67 labeling index (LI) in univariate regression analysis, and associated with Ki-67 LI and axillary lymph node metastasis in multivariate regression analysis. Microlymphatic density was associated histologic grade 3, mean elasticity value, and Ki-67 LI in univariate regression analysis. In multivariate regression analysis, microlymphatic density was correlated with mean elasticity value.

CONCLUSION:

In breast cancer, tumor stiffness correlates with lymphangiogenesis and poor prognostic factors.

KEYWORDS:

Breast neoplasms; elasticity imaging techniques; fibrosis; lymphangiogenesis

PMID:
26996557
PMCID:
PMC4800347
DOI:
10.3349/ymj.2016.57.3.599
[Indexed for MEDLINE]
Free PMC Article

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