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Prostaglandins Leukot Essent Fatty Acids. 2016 Aug;111:25-35. doi: 10.1016/j.plefa.2016.02.002. Epub 2016 Feb 17.

Vegetable oils rich in alpha linolenic acid increment hepatic n-3 LCPUFA, modulating the fatty acid metabolism and antioxidant response in rats.

Author information

1
Lipid Center, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.
2
Lipid Center, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile. Electronic address: rvalenzuelab@med.uchile.cl.
3
Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.
4
Medical Technology Department, Faculty of Medicine, University of Chile, Santiago, Chile.
5
Lipid Center, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile; Faculty of Medicine, Universidad de Los Andes, Santiago, Chile.

Abstract

Alpha-linolenic acid (C18:3 n-3, ALA) is an essential fatty acid and the metabolic precursor of long-chain polyunsaturated fatty acids (LCPUFA) from the n-3 family with relevant physiological and metabolic roles: eicosapentaenoic acid (C20:5 n-3, EPA) and docosahexaenoic acid (C22:6 n-3, DHA). Western diet lacks of suitable intake of n-3 LCPUFA and there are recommendations to increase the dietary supply of such nutrients. Seed oils rich in ALA such as those from rosa mosqueta (Rosa rubiginosa), sacha inchi (Plukenetia volubis) and chia (Salvia hispanica) may constitute an alternative that merits research. This study evaluated hepatic and epididymal accretion and biosynthesis of n-3 LCPUFA, the activity and expression of Δ-5 and Δ-6 desaturase enzymes, the expression and DNA-binding activity of PPAR-α and SREBP-1c, oxidative stress parameters and the activity of antioxidative enzymes in rats fed sunflower oil (SFO, 1% ALA) as control group, canola oil (CO, 10% ALA), rosa mosqueta oil (RMO, 33% ALA), sacha inchi oil (SIO, 49% ALA) and chia oil (ChO, 64% ALA) as single lipid source. A larger supply of ALA increased the accretion of n-3 LCPUFA, the activity and expression of desaturases, the antioxidative status, the expression and DNA-binding of PPAR-α, the oxidation of fatty acids and the activity of antioxidant enzymes, whereas the expression and DNA-binding activity of SREBP-1c transcription factor and the biosynthetic activity of fatty acids declined. Results showed that oils rich in ALA such as SIO and ChO may trigger metabolic responses in rats such as those produced by n-3 PUFA.

KEYWORDS:

Alpha linolenic acid (ALA); Metabolic and antioxidative responses; Vegetable oils rich in ALA; n-3 LCPUFA

PMID:
26995676
DOI:
10.1016/j.plefa.2016.02.002
[Indexed for MEDLINE]

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