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Drug Discov Today. 2016 Jun;21(6):962-76. doi: 10.1016/j.drudis.2016.03.002. Epub 2016 Mar 17.

Effect of food and acid-reducing agents on the absorption of oral targeted therapies in solid tumors.

Author information

1
Radboud university medical center, Department of Medical Oncology, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands. Electronic address: annelieke.willemsen@radboudumc.nl.
2
Radboud university medical center, Department of Pharmacy, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands.
3
Jeroen Bosch Hospital, Department of Medical Oncology, P.O. Box 90153, 5200 ME, 's-Hertogenbosch, The Netherlands.
4
Radboud university medical center, Department of Medical Oncology, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands.

Abstract

Oral targeted therapies represent an increasingly important group of drugs within modern oncology. With the shift from intravenously to orally administered drugs, drug absorption is a newly introduced factor in drug disposition. The process of absorption can have a large effect on inter- and intrasubject variability in drug exposure and thereby potentially treatment benefit or the severity of toxicities. The intake of oral targeted therapies with food and concomitant use of acid-reducing agents (ARAs) can significantly affect drug absorption. The size and direction of the effect of food and ARAs on drug absorption varies among drugs as a result of different chemical characteristics. Therefore, an awareness and understanding of these effects for each drug is essential to optimize patient outcomes.

PMID:
26995271
DOI:
10.1016/j.drudis.2016.03.002
[Indexed for MEDLINE]

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