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J Ren Nutr. 2016 Jul;26(4):258-64. doi: 10.1053/j.jrn.2016.02.002. Epub 2016 Mar 16.

Psoas Muscle Cross-sectional Area as a Measure of Whole-body Lean Muscle Mass in Maintenance Hemodialysis Patients.

Author information

1
Department of Radiology, University of Utah School of Medicine, Salt Lake City, Utah. Electronic address: glen.morrell@hsc.utah.edu.
2
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
3
Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah.
4
Department of Radiology, University of Utah School of Medicine, Salt Lake City, Utah.
5
Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah; Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah.

Abstract

OBJECTIVE:

We investigate whether psoas or paraspinous muscle area measured on a single L4-L5 image is a useful measure of whole lean body mass (LBM) compared to dedicated midthigh magnetic resonance imaging (MRI).

DESIGN:

Observational study.

SETTING:

Outpatient dialysis units and a research clinic.

SUBJECTS:

One hundred five adult participants on maintenance hemodialysis. No control group was used.

INTERVENTION:

Psoas muscle area, paraspinous muscle area, and midthigh muscle area (MTMA) were measured by magnetic resonance imaging.

MAIN OUTCOME MEASURE:

LBM was measured by dual-energy absorptiometry scan.

RESULTS:

In separate multivariable linear regression models, psoas, paraspinous, and MTMA were associated with increase in LBM. In separate multivariate logistic regression models, C statistics for diagnosis of sarcopenia (defined as <25th percentile of LBM) were 0.69 for paraspinous muscle area, 0.81 for psoas muscle area, and 0.89 for MTMA. With sarcopenia defined as <10th percentile of LBM, the corresponding C statistics were 0.71, 0.92, and 0.94.

CONCLUSIONS:

We conclude that psoas muscle area provides a good measure of whole-body muscle mass, better than paraspinous muscle area but slightly inferior to midthigh measurement. Hence, in body composition studies a single axial MR image at the L4-L5 level can be used to provide information on both fat and muscle and may eliminate the need for time-consuming measurement of muscle area in the thigh.

PMID:
26994780
PMCID:
PMC4912956
DOI:
10.1053/j.jrn.2016.02.002
[Indexed for MEDLINE]
Free PMC Article

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