Format

Send to

Choose Destination
J Vasc Surg Venous Lymphat Disord. 2015 Apr;3(2):135-41.e1. doi: 10.1016/j.jvsv.2014.11.002. Epub 2015 Mar 13.

Subsequent arterial ischemic events in patients receiving anticoagulant therapy for venous thromboembolism.

Collaborators (129)

Arcelus JI, Arroyo M, Ballaz A, Barba R, Barrón M, Barrón-Andrés B, Bascuñana J, Bedate P, Blanco-Molina A, Bueso T, Casado I, Del Molino F, Del Toro J, Falgá C, Fernández-Capitán C, Font C, Fuentes MI, Gallego P, García-Bragado F, Gavín O, Gómez V, González J, González-Bachs E, Grau E, Guil M, Guijarro R, Gutiérrez J, Hernández L, Hernández-Huerta S, Jara-Palomares L, Jaras MJ, Jiménez D, Lecumberri R, Lobo JL, López-Jiménez L, López-Sáez JB, Lorente MA, Lorenzo A, Luque JM, Madridano O, Macià M, Maestre A, Marchena PJ, Martín M, Martín-Villasclaras JJ, Monreal M, Mora JM, Mosquera D, Muñoz FJ, Nauffal MD, Nieto JA, Núñez MJ, Ogea JL, Otero R, Pedrajas JM, Peris ML, Riera-Mestre A, Rivas A, Rodríguez-Dávila MA, Román P, Rosa V, Ruiz J, Ruiz-Gamietea A, Ruiz-Giménez N, Sahuquillo JC, Samperiz A, Sánchez Muñoz-Torrero JF, Soler S, Suriñach JM, Tiberio G, Tilvan RM, Tolosa C, Trujillo J, Uresandi F, Valdés M, Valero B, Valle R, Vela J, Vidal G, Vilar C, Villalobos A, Villalta J, Malý R, Hirmerova J, Miklo Sová M, Salgado E, Bertoletti L, Bura-Riviere A, Farge-Bancel D, Mahe I, Merah A, Quere I, Schellong S, Babalis D, Papadakis M, Tzinieris I, Braester A, Brenner B, Tzoran I, Zeltser D, Barillari G, Ciammaichella M, Di Micco P, Duce R, Maida R, Dalla Valle F, Piovella C, Poggio R, Prandoni P, Quintavalla R, Rota L, Schenone A, Tiraferri E, Tonello D, Tufano A, Visonà A, Zalunardo B, Fernandes M, Gonçalves F, Santos M, Saraiva M, Sousa R, Bosevski M, Kovacevic D, Alatri A, Aujeski D, Bounameaux H, Calanca L, Mazzolai L.

Author information

1
Department of Internal Medicine, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain.
2
Department of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
3
Department of Internal Medicine, Hospital Universitario La Paz, Madrid, Spain.
4
Department of Pneumonology, Hospital General Universitario de Alicante, Alicante, Spain.
5
Department of Cardiothoracic and Vascular Sciences, University of Padua, Padua, Italy.
6
Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain. Electronic address: mmonreal.germanstrias@gencat.cat.

Abstract

OBJECTIVE:

Patients with acute venous thromboembolism (VTE) are at increased risk for the development of subsequent arterial ischemic events unrelated to the diagnosis of VTE. Accurate identification of VTE patients at increased risk for ischemic events during the course of anticoagulation may help to select those who would potentially benefit from concomitant therapy with anticoagulants and antiplatelets.

METHODS:

We used the Registro Informatizado de Enfermedad TromboEmbólica (RIETE) Registry to assess the rate and severity of subsequent ischemic events (ie, stroke, myocardial infarction, lower limb amputation, or mesenteric ischemia) appearing during the course of anticoagulant therapy and tried to identify risk factors for these events.

RESULTS:

From February 2009 to March 2014, 23,370 patients were recruited: 12,397 initially presenting with pulmonary embolism (PE) and 10,973 with deep venous thrombosis. During the course of anticoagulation (mean, 9.2 months), 597 patients developed recurrent VTE, 652 bled, 162 had ischemic events (stroke, 86; myocardial infarction, 53; limb amputation, 13; mesenteric ischemia, 11), and 2063 died. Of these, 29 patients died of recurrent PE, 83 of bleeding, and 53 of the ischemic events. On multivariable analysis, cancer (hazard ratio [HR], 1.77; 95% confidence interval [CI], 1.21-2.61), chronic lung disease (HR, 1.54; 95% CI, 1.05-2.26), renal insufficiency (HR, 1.72; 95% CI, 1.25-2.36), anemia (HR, 1.54; 95% CI, 1.11-2.14), prior artery disease (HR, 1.84; 95% CI, 1.29-2.64), and diabetes (HR, 1.58; 95% CI, 1.10-2.27) independently predicted the risk for ischemic events. Most of these variables also predicted major bleeding (cancer, chronic lung disease, renal insufficiency, anemia, and prior artery disease) or recurrent PE (cancer, chronic lung disease, anemia, and prior artery disease).

CONCLUSIONS:

In patients receiving anticoagulation for VTE, the mortality due to PE recurrences was lower than the mortality due to ischemic events. Most independent predictors for ischemic events were also predictors for major bleeding and for recurrent PE.

PMID:
26993830
DOI:
10.1016/j.jvsv.2014.11.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center