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J Diabetes Complications. 2016 Jul;30(5):798-802. doi: 10.1016/j.jdiacomp.2016.02.018. Epub 2016 Feb 27.

Association between serum uric acid related genetic loci and diabetic kidney disease in the Chinese type 2 diabetes patients.

Author information

1
Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233 China.
2
Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233 China; Shanghai Jiao Tong University Affiliated Sixth People's Hospital, South Campus, Shanghai 201499, China. Electronic address: alfredhc@sjtu.edu.cn.
3
Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233 China. Electronic address: wpjia@sjtu.edu.cn.

Abstract

AIM:

We aimed to investigate the association between uric acid related genetic loci and DKD susceptibility in type 2 diabetes patients.

METHODS:

Seventeen single nucleotide polymorphisms (SNPs) from thirteen loci related to serum uric acid were genotyped in 2,892 type 2 diabetes patients. Associations between SNPs and uric acid, SNPs and quantitative traits related to DKD or its susceptibility were evaluated.

RESULTS:

In this study, uric acid showed a strong association with DKD (OR=1.006, p<0.0001). GCKR rs780094, SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142, SLC22A12 rs505802 and NRXN2 rs506338 were positively associated with serum uric acid (p=3.79E-05, 0.0002, 2.04E-10, 2.23E-09, 0.0018 and 0.0015, respectively). SLC2A9 rs11722228 and SF1 rs606458 were significantly associated with DKD (OR=0.864, p=0.0440; OR=1.223, p=0.0038). SLC2A9 rs3775948 and ABCG2 rs2231142 were associated with DKD marginally (OR=0.878, p=0.0506; OR=0.879, p=0.0698). SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142 and SF1 rs606458 were significantly associated with the estimated glomerular filtration rate (p=0.0005, 0.0006, 0.0003, and 0.0424, respectively).

CONCLUSIONS:

Our study indicated that the uric acid related alleles of SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142 might affect DKD susceptibility and possibly through non-uric acid pathway in the Chinese people with type 2 diabetes.

KEYWORDS:

ABCG2; Diabetic kidney disease; SLC2A9; Single nucleotide polymorphisms; Uric acid

PMID:
26993665
DOI:
10.1016/j.jdiacomp.2016.02.018
[Indexed for MEDLINE]

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