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Ann Pathol. 2016 Apr;36(2):105-10. doi: 10.1016/j.annpat.2015.12.001. Epub 2016 Mar 16.

[Metastasis revealing malignant peritoneum mesothelioma: About the difficulty to identify the primary tumors].

[Article in French]

Author information

1
Service de pathologie, CHRU de Besançon, 2, boulevard A.-Fleming, 25000 Besançon, France.
2
Besançon pathologie, 16, rue Professeur-Paul-Milleret CS 51369 25006 Besançon cedex, France.
3
Service de radiologie, CHRU de Besançon, 2, boulevard A.-Fleming, 25000 Besançon, France; Université de Franche-Comté, 25000 Besançon, France.
4
Service de pathologie, CHRU de Besançon, 2, boulevard A.-Fleming, 25000 Besançon, France; Université de Franche-Comté, 25000 Besançon, France. Electronic address: svalmary@univ-fcomte.fr.
5
Hôpital Lyon Sud, 69495 Pierre-Bénite, France.

Abstract

Peritoneal malignant mesothelioma is a rare and extremely aggressive tumor that is sometimes difficult to diagnose. We report two cases of metastatic malignant peritoneal mesothelioma. In one case, malignant metastatic cells were identified in cervical lymph nodes while in the other case, the cells were found in the liver. In both cases, metastases were identified before discovering the primary tumor. This led to the misdiagnosis of carcinoma of unknown origin. Nevertheless, the histological and immuno-histochemical patterns were typical of malignant mesothelioma. Regarding metastasis of unknown origin, a differentiation of epithelioid peritoneal malignant mesothelioma and adenocarcinoma proved to be difficult. Therefore, we discuss the diagnostic usefulness of immuno-histochemical mesothelioma markers.

KEYWORDS:

Epithelioid mesothelioma; Expert network; Malignant peritonel mesothelioma; Metastasis; Mésothéliome malin péritonéal; Mésothéliome épithélioïde; Métastases; RENA-PATH; Réseau d’expert

PMID:
26993587
DOI:
10.1016/j.annpat.2015.12.001
[Indexed for MEDLINE]

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