Format

Send to

Choose Destination
Biochim Biophys Acta. 2016 Apr;1865(2):255-65. doi: 10.1016/j.bbcan.2016.03.005. Epub 2016 Mar 16.

Cytokines in cancer drug resistance: Cues to new therapeutic strategies.

Author information

1
Raybiotech, Inc., 3607 Parkway Lane, Norcross, GA, USA.
2
RayBiotech, Inc., Guangzhou, No. 79 Ruihe Road, Huangpu District, Guangzhou, China.
3
Department of Gynaecologic Oncology, Cancer Institute and Hospital, Guangzhou Medical University, Guangzhou, China.
4
Department of Pharmaceutical Sciences, College of Pharmacy and Health Science, St. John's University, Queens, NY, USA.
5
Sun Yat-sen University Cancer Center, Guangzhou, China.
6
Raybiotech, Inc., 3607 Parkway Lane, Norcross, GA, USA; RayBiotech, Inc., Guangzhou, No. 79 Ruihe Road, Huangpu District, Guangzhou, China; South China Biochip Research Center, No. 79 Ruihe Road, Huangpu District, Guangzhou, China.

Abstract

The development of oncoprotein-targeted anticancer drugs is an invaluable weapon in the war against cancer. However, cancers do not give up without a fight. They may develop multiple mechanisms of drug resistance, including apoptosis inhibition, drug expulsion, and increased proliferation that reduce the effectiveness of the drug. The collective work of researchers has highlighted the role of cytokines in the mechanisms of cancer drug resistance, as well as in cancer cell progression. Furthermore, recent studies have described how specific cytokines secreted by cancer stromal cells confer resistance to chemotherapeutic treatments. In order to gain a better understanding of mechanism of cancer drug resistance and a prediction of treatment outcome, it is imperative that correlations are established between global cytokine profiles and cancer drug resistance. Here we discuss the recent discoveries in this field of research and discuss their implications for the future development of effective anti-cancer medicines.

KEYWORDS:

Antibody array; Cancer drug resistance; Cytokine; Multiplex immunoassay; Stromal cells; Tumor microenvironment

PMID:
26993403
DOI:
10.1016/j.bbcan.2016.03.005
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center