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Placenta. 2016 Mar;39:147-50. doi: 10.1016/j.placenta.2016.01.013. Epub 2016 Jan 26.

Ly49 knockdown in mice results in aberrant uterine crypt formation and impaired blastocyst implantation.

Author information

1
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
2
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
3
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. Electronic address: croya@queensu.ca.

Abstract

Genetic knockdown (KD) of the mouse Ly49 receptor family is reported to result in infertility despite the presence of zona-enclosed blastocysts in the uterus. Ly49 receptors regulate leukocyte functions particularly Natural Killer (NK) cell functions and are analogous to human killer immunoglobulin-like receptors (KIRs). Histological analyses of gd3.5-4.5 B6.Ly49(KD) uteri identified hatched but retarded blastocysts with pyknotic nuclei, aberrant endometrial crypt formation and impaired uterine lumen closure accompanied by a lack of primary decidualization These data support peri-implantation roles for leukocytes expressing the Ly49 receptor repertoire and may give insight into KIR-based regulation of human infertility.

KEYWORDS:

Decidual leukocytes; Ly49 gene family; Mouse implantation

PMID:
26992687
DOI:
10.1016/j.placenta.2016.01.013
[Indexed for MEDLINE]

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