Format

Send to

Choose Destination
Br J Haematol. 2016 Jul;174(1):148-52. doi: 10.1111/bjh.14040. Epub 2016 Mar 17.

Morbidity and mortality of sickle cell disease patients starting intermittent haemodialysis: a comparative cohort study with non- Sickle dialysis patients.

Author information

1
AP-HP (Assistance Publique-Hôpitaux de Paris), Groupe Hospitalier Henri Mondor-Albert Chenevier, Service de Néphrologie et Transplantation, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Centre de Référence Maladie Rare Syndrome Néphrotique Idiopathique, Créteil, France.
2
Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunity-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil, France.
3
AP-HP, Groupe Hospitalier Henri Mondor-Albert Chenevier, Service de Santé Publique, Créteil, France.
4
UPEC, DHU A-TVB (Aging-Thorax-Vessels-Blood), IMRB, EA 4393 CEpiA (Clinical Epidemiology And Ageing Unit), Créteil, France.
5
Université Paris Descartes, INSERM UMRS 1138 Equipe 22, Paris, France.
6
AP-HP, Hôpital Necker Enfants Malades, Biostatistics & Ile de France REIN Registry Epidemiologic Units, Paris, France.
7
AP-HP, Centre de Référence des Syndromes Drépanocytaires Majeurs, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France.
8
AP-HP, Service de Médecine Interne, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France.
9
UPEC, INSERM 955, Equipe 2 Emergente, Créteil, France.
10
Laboratoire Régional d'Histocompatibilité, Hôpital Saint-Louis, Paris, France.
11
Pôle Rein-Simulation, Direction Générale Médicale et Scientifique, Agence de la Biomédecine, Saint Denis, France.
12
Inserm U1018, Centre de Recherches en Épidémiologie et Santé des Populations, Villejuif, France.
13
APHP, Département d'Hématologie et d'Immunologie Biologiques, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France.
14
UPEC, INSERM U955, Equipe 9, DHU VIC, Créteil, France.
15
APHP, Département de Cardiologie and Réseau Amylose Mondor, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France.
16
UPEC, INSERM U955, Groupe de Recherche Clinique (GRC) Amyloid Research Insitute, DHU A-TVB, Créteil, France.

Abstract

We performed a retrospective study to assess the changes in clinical, biological and heart echocardiographic parameters in 32 sickle cell disease (SCD) patients beginning haemodialysis. Acute SCD-related complications were similar at 6 months before and 6 months after the initiation of haemodialysis. Median haemoglobin level did not change significantly, but the need for blood transfusions increased (P < 0·001). The 5-year incidence of death was higher in SCD patients (P < 0·0001). The 5-year likelihood of receiving a renal graft was lower in SCD patients (P = 0·022). Our findings suggest that SCD patients have poorer survival and a lower likelihood of receiving a renal graft.

KEYWORDS:

dialysis; kidney; sickle cell disease; survival; vaso-occlusive crises

PMID:
26992059
DOI:
10.1111/bjh.14040
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center