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J Med Food. 2016 Apr;19(4):427-33. doi: 10.1089/jmf.2015.0133. Epub 2016 Mar 18.

Cranberry Product Decreases Fat Accumulation in Caenorhabditis elegans.

Author information

1
1 Department of Food Science, University of Massachusetts , Amherst, Massachusetts, USA .
2
2 Amherst Regional High School , Amherst, Massachusetts, USA.

Abstract

Cranberry phenolic compounds have been linked to many health benefits. A recent report suggested that cranberry bioactives inhibit adipogenesis in 3T3-L1 adipocytes. Thus, we investigated the effects and mechanisms of the cranberry product (CP) on lipid metabolism using the Caenorhabditis elegans (C. elegans) model. CP (0.016% and 0.08%) dose-dependently reduced overall fat accumulation in C. elegans (N2, wild type) by 43% and 74%, respectively, without affecting its pumping rates or locomotive activities. CP decreased fat accumulation in aak-2 (an ortholog of AMP-activated kinase α) and tub-1 (an ortholog of TUBBY) mutants significantly, but only minimal effects were observed in sbp-1 (an ortholog of sterol response element-binding protein-1) and nhr-49 (an ortholog of peroxisome proliferator-activated receptor-α) mutant strains. We further confirmed that CP downregulated sbp-1, cebp, and hosl-1 (an ortholog of hormone-sensitive lipase homolog) expression, while increasing the expression of nhr-49 in wild-type C. elegans. These results suggest that CP could effectively reduce fat accumulation in C. elegans dependent on sbp-1, cebp, and nhr-49, but not aak-2 and tub-1.

KEYWORDS:

C. elegans; cranberry; fat accumulation; nhr-49; sbp-1

PMID:
26991055
PMCID:
PMC5076481
DOI:
10.1089/jmf.2015.0133
[Indexed for MEDLINE]
Free PMC Article

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