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J Biomed Mater Res B Appl Biomater. 2017 Jul;105(5):1075-1082. doi: 10.1002/jbm.b.33650. Epub 2016 Mar 15.

Polydimethyl siloxane based nanocomposites with antibiofilm properties for biomedical applications.

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Bioengineering and Drug Design Lab, Department of Biotechnology, Indian Institute of Technology, Chennai, India.
Biofouling and Biofilm Processes Section, Bhabha Atomic Research Centre, Kalpakkam, India.
Surface and Nanoscience Division, Indira Gandhi Centre for Atomic Research, Kalpakkam, India.


Polydimethyl siloxane (PDMS) is an excellent implant material for biomedical applications, but often fails as it is prone to microbial colonization which forms biofilms. In the present study CuO, CTAB capped CuO, and ZnO nanoparticles were tested as nanofillers to enhance the antibiofilm property of PDMS against Staphylococcus aureus and Escherichia coli. In general S. aurues (Gram positive and more hydrophobic) favor PDMS surface than glass while E. coli (Gram negative and more hydrophilic) behaves in a reverse way. Incorporation of nanofillers renders the PDMS surface antibacterial and reduces the attachment of both bacteria. These surfaces are also not cytotoxic nor show any cell damage. Contact angle of the material and the cell surface hydrophobicity influenced the extent of bacterial attachment. Cell viability in biofilms was dependent on the antimicrobial property of the nanoparticles incorporated in the PDMS matrix. Simple regression relationships were able to predict the bacterial attachment and number of dead cells on these nanocomposites. Among the nanocomposites tested, PDMS incorporated with CTAB (cetyl trimethylammonium bromide)-capped CuO appears to be the best antibacterial material with good cyto-compatibility.


E. coli; S. aureus; biofilm; nanocomposites; polydimethyl siloxane

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