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Depress Anxiety. 2016 Jul;33(7):667-75. doi: 10.1002/da.22487. Epub 2016 Mar 17.

IMPACT OF SPECIFIC PHOBIA ON THE RISK OF ONSET OF MENTAL DISORDERS: A 10-YEAR PROSPECTIVE-LONGITUDINAL COMMUNITY STUDY OF ADOLESCENTS AND YOUNG ADULTS.

Author information

1
Division of Clinical Psychology and Epidemiology, Department of Psychology, University of Basel, Switzerland.
2
Max Planck Institute of Psychiatry, Munich, Germany.
3
Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
4
Behavioral Epidemiology, Technische Universität Dresden, Dresden, Germany.

Erratum in

Abstract

BACKGROUND:

The role of specific phobia as a potentially important psychopathological precursor condition to more severe mental disorders is understudied. We examined the prospective-longitudinal association of early childhood/adolescent phobia with subsequent mental disorders and the proportion of outcome disease incidence attributable to specific phobia simultaneously for a broad range of disorders.

METHODS:

N = 2210 14- to 24-year-old community subjects were followed up for 10 years. DSM-IV-specific phobia as exposure and a broad range of DSM-IV mental disorders as outcomes were assessed with the DSM-IV/M-CIDI. Logistic regressions, adjusting for confounders, were used to estimate the associations of specific phobia with the subsequent onset of outcome disorders.

RESULTS:

Baseline specific phobia predicted the subsequent first onset of anxiety disorders [panic disorder: risk ratio (RR) = 4.38, 95% confidence interval (2.34, 8.21); generalized anxiety disorder: RR = 4.10 (2.19, 7.69); posttraumatic stress disorder: RR = 2.15 (1.13, 4.10); obsessive-compulsive disorder: RR = 3.79 (1.63, 8.82)], affective disorders [major depression: RR = 1.54 (1.16, 2.03); bipolar disorder: RR = 2.20 (1.10, 4.41); dysthymia: RR = 2.75 (1.48, 5.11)], pain disorder: RR = 1.52 (1.14, 2.02), and eating disorders: RR = 2.27 (1.14, 4.51). Population attributable fractions (PAFs; i.e., proportion of outcome disease incidence in the total population attributable to specific phobia) were highest for panic disorder (PAF = 33.93), generalized anxiety disorder (PAF = 32.3), and obsessive-compulsive disorders (PAF = 30.2).

CONCLUSION:

This study provides strong evidence that specific phobia is an early onset disorder predicting the subsequent onset of a range of disorders. Future studies should examine the underlying mechanisms and the potential of using specific phobia as a target for prevention of subsequent psychopathology.

KEYWORDS:

anxiety/anxiety disorders; bipolar disorder, depression, epidemiology, gad/generalized anxiety disorder, mood disorders, substance use disorders

PMID:
26990012
DOI:
10.1002/da.22487
[Indexed for MEDLINE]

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