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Rep Biochem Mol Biol. 2015 Apr;3(2):62-7.

Protective effects of Withania somnifera root on inflammatory markers and insulin resistance in fructose-fed rats.

Author information

1
Department of Pharmacology, Zahedan University of Medical Sciences, Zahedan, Iran.
2
Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran.
3
Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorram Abad, Iran.
4
Department of Physiology, Iran University of Medical Sciences, Tehran, Iran.

Abstract

BACKGROUND:

We investigated the effects of Withania somnifera root (WS) on insulin resistance, tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6) in fructose-fed rats.

METHODS:

Forty-eight Wistar-Albino male rats were randomly divided into four groups (n=12); Group I as control, Group II as sham-treated with WS by 62.5mg/g per diet, Group III fructose-fed rats received 10%W/V fructose, and Group IV fructose- and WS-fed rats. After eight weeks blood samples were collected to measure glucose, insulin, IL-6, and TNF-α levels in sera.

RESULTS:

Blood glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-R), IL-6, and TNF-α levels were all significantly greater in the fructose-fed rats than in the controls. Treatment with WS significantly (P < 0.05) inhibited the fructose-induced increases in glucose, insulin, HOMA-R, IL-6, and TNF-α.

CONCLUSION:

Our data suggest that WS normalizes hyperglycemia in fructose-fed rats by reducing inflammatory markers and improving insulin sensitivity.

KEYWORDS:

IL-6; Insulin resistance; TNF- α; Withania somnifera

PMID:
26989739
PMCID:
PMC4757043

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