Format

Send to

Choose Destination
Nat Commun. 2016 Mar 18;7:10923. doi: 10.1038/ncomms10923.

Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells.

Author information

1
Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), via Ramarini 32, Monterotondo 00015, Italy.
2
Division of Neuroscience, University Pablo Olavide, Carretera de Utrera-km 1, Sevilla 41013, Spain.
3
Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, 69117 Heidelberg, Germany.
4
Schaller Research Group on Neuropeptides, German Cancer Research Center DKFZ, Central Institute of Mental Health, CellNetwork Cluster of Excellence, University of Heidelberg, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

Abstract

The hippocampus is critical for the acquisition and retrieval of episodic and contextual memories. Lesions of the dentate gyrus, a principal input of the hippocampus, block memory acquisition, but it remains unclear whether this region also plays a role in memory retrieval. Here we combine cell-type specific neural inhibition with electrophysiological measurements of learning-associated plasticity in behaving mice to demonstrate that dentate gyrus granule cells are not required for memory retrieval, but instead have an unexpected role in memory maintenance. Furthermore, we demonstrate the translational potential of our findings by showing that pharmacological activation of an endogenous inhibitory receptor expressed selectively in dentate gyrus granule cells can induce a rapid loss of hippocampal memory. These findings open a new avenue for the targeted erasure of episodic and contextual memories.

PMID:
26988806
PMCID:
PMC4802048
DOI:
10.1038/ncomms10923
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center