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Phytother Res. 2016 Jun;30(6):981-7. doi: 10.1002/ptr.5603. Epub 2016 Mar 14.

Slimming and Appetite-Suppressing Effects of Caraway Aqueous Extract as a Natural Therapy in Physically Active Women.

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Sports Centre, University of Malaya, 50603, Kuala Lumpur, Malaysia.
National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, 1981619573, Iran.
Department of Science and Technology Studies, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Natural Products Inc., Evanston, IL, 60203, USA.
Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, 32601, USA.


Following the current 'Globesity' trend, there is an increasing demand for alternative natural therapies for weight management. Numerous phytoconstituents reduce body weight through suppressing appetite and reducing food intake. Caraway (Carum carvi L.) is one of the medicinal plants that is traditionally used for weight loss. In this study, the appetite-suppressing effects of caraway aqueous extract (CAE) on 70 aerobically trained, overweight, and obese women were examined in a triple-blind, placebo-controlled, clinical study. Subjects were randomly allocated into placebo and experimental groups and consumed either 30 mL/day of CAE or placebo without changing their diet or physical activity over a period of 90 days. Calorie and macronutrient intake and anthropometric indices were measured before and after the intervention. In addition, appetite changes were assessed through a visual analog scale and an ad libitum pizza test. After the intervention, the results showed a significant reduction in appetite levels and carbohydrate intake of the experimental group compared with the placebo group. All of the anthropometric indices were reduced significantly in CAE compared with placebo group (p < 0.01). These preliminary outcomes suggest that a dietary CAE might be effective in weight management of physically active, adult females, reducing their body size and hunger level.


active plant constituents; appetite suppression; food intake; obesity; polyphenols; receptor

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