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Dev Biol. 2016 May 15;413(2):153-159. doi: 10.1016/j.ydbio.2016.03.014. Epub 2016 Mar 14.

Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart.

Author information

1
Department of Cardiology, Boston Children's Hospital, Boston, MA, USA.
2
Department of Pediatric Cardiology and Critical Care, Medizinische Hochschule Hannover, Hannover, Germany.
3
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
4
Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
#
Contributed equally

Abstract

A subset of macrophages that reside in adult tissues originate from the fetal yolk sac, while others derive from circulating monocytes. These ontologically different macrophage subsets have distinct roles in tissue injury responses, with the embryonic population overall having beneficial activity in cardiac repair. Here we show that fetal yolk macrophages are recruited to a niche within and just below the epicardium, the mesothelial covering of the heart. The epicardium was required for establishment of yolk sac macrophages in this region of the fetal heart, and this function of epicardium depended on its expression of the transcription factor WT1. Thus, tissue-specific cues and transcriptional programs recruit or retain embryonic macrophages in their final abodes, where they help to shape organ homeostasis and injury responses.

KEYWORDS:

Embryonic macrophage; Epicardium

PMID:
26988120
PMCID:
PMC5064848
DOI:
10.1016/j.ydbio.2016.03.014
[Indexed for MEDLINE]
Free PMC Article

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