Carbon-Quantum-Dots-Loaded Mesoporous Silica Nanocarriers with pH-Switchable Zwitterionic Surface and Enzyme-Responsive Pore-Cap for Targeted Imaging and Drug Delivery to Tumor

Zhongning Liu; Xin Chen; Xiaojin Zhang; John Justin Gooding; Yongsheng Zhou

doi:10.1002/adhm.201600002

Carbon-Quantum-Dots-Loaded Mesoporous Silica Nanocarriers with pH-Switchable Zwitterionic Surface and Enzyme-Responsive Pore-Cap for Targeted Imaging and Drug Delivery to Tumor

Adv Healthc Mater. 2016 Jun;5(12):1401-7. doi: 10.1002/adhm.201600002. Epub 2016 Mar 14.

Authors

Zhongning Liu¹, Xin Chen², Xiaojin Zhang³, John Justin Gooding⁴, Yongsheng Zhou⁵

Affiliations

¹ Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
² School of Chemical Engineering and Technology, Shanxi Key Laboratory of Energy Chemical Process Intensification, Xi'an Jiaotong University, Xi'an, 710049, China.
³ Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, 430072, China.
⁴ School of Chemistry and Australian Centre for NanoMedicine, University of New South Wales, Sydney, 2052, Australia.
⁵ Department of Prosthodontics, National Engineering Lab for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, Beijing, 100081, China.

PMID: 26987989
DOI: 10.1002/adhm.201600002

Abstract

Mesoporous silica nanocarriers with pH-switchable antifouling zwitterionic surface, enzyme responsive drug release properties and blue fluorescence are reported. Prolonged circulation in the blood system with zero premature release as well as efficient cellular uptake and intracellular drug release in tumor tissue are achieved.

Keywords: dual-stimuli responsiveness; mesoporous silica nanocarriers; selective cell imaging; switchable antifouling; tumor targeting drug delivery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Drug Carriers* / chemistry
Drug Carriers* / pharmacology
Humans
Hydrogen-Ion Concentration
Neoplasms / drug therapy*
Neoplasms / metabolism
Neoplasms / pathology
Porosity
Quantum Dots* / chemistry
Quantum Dots* / therapeutic use
Silicon Dioxide* / chemistry
Silicon Dioxide* / pharmacology

Substances

Drug Carriers
Silicon Dioxide