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J Clin Periodontol. 2016 Aug;43(8):668-83. doi: 10.1111/jcpe.12546. Epub 2016 May 28.

Twenty years of enamel matrix derivative: the past, the present and the future.

Author information

1
Department of Periodontology, Nova Southeastern University, Fort Lauderdale, Florida, USA.
2
Department of Periodontology, University of Bern, Bern, Switzerland.
3
Department of Periodontics, Dental School, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
4
Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York, NY, USA.
5
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
6
Department of Periodontology and Dental Implantology, Dental School, Tel-Aviv University, Tel-Aviv, Israel.
7
Department of Periodontology, Queen Marry University of London, London, UK.
8
Department of Biomaterials, Faculty of Dentistry, University of Oslo, Oslo, Norway.
9
Section of Experimental Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany.
10
New York University, College of Dentistry, New York, NY, USA.
11
Department of Periodontology, Malmö University, Malmö, Sweden.
12
Department of Oral Implantology, Wuhan University, Wuhan, China.
13
Department of Periodotology, Research Centre for the Study of Periodontal and Peri-implant Diseases, University of Ferrara, Ferrara, Italy.
14
Department of Operative Dentistry and Periodontology, University Medical Center, Mainz, Germany.
15
Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
16
Accademia Toscana di Ricerca Odontostomatologica, Firenze, Italy.
17
European Research Group on Periodontology (ERGOPerio), Genova, Italy.
18
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
19
Foundation IRCCS Ca' Granda Polyclinic, Milan, Italy.
20
Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany.

Abstract

BACGROUND:

On June 5th, 2015 at Europerio 8, a group of leading experts were gathered to discuss what has now been 20 years of documented evidence supporting the clinical use of enamel matrix derivative (EMD). Original experiments led by Lars Hammarström demonstrated that enamel matrix proteins could serve as key regenerative proteins capable of promoting periodontal regeneration including new cementum, with functionally oriented inserting new periodontal ligament fibres, and new alveolar bone formation. This pioneering work and vision by Lars Hammarström has paved the way to an enormous amount of publications related to its biological basis and clinical use. Twenty years later, it is clear that all these studies have greatly contributed to our understanding of how biologics can act as mediators for periodontal regeneration and have provided additional clinical means to support tissue regeneration of the periodontium.

AIMS:

This review article aims to: (1) provide the biological background necessary to understand the rational for the use of EMD for periodontal regeneration, (2) present animal and human histological evidence of periodontal regeneration following EMD application, (3) provide clinically relevant indications for the use of EMD and (4) discuss future avenues of research including key early findings leading to the development of Osteogain, a new carrier system for EMD specifically developed with better protein adsorption to bone grafting materials.

KEYWORDS:

EMD; Emdogain; Osteogain; enamel matrix derivative; enamel matrix proteins; intrabony defect; periodontal regeneration

PMID:
26987551
DOI:
10.1111/jcpe.12546
[Indexed for MEDLINE]

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