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PLoS One. 2016 Mar 17;11(3):e0151441. doi: 10.1371/journal.pone.0151441. eCollection 2016.

Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men.

Author information

1
Department of Community Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
2
Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
3
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
4
Department of Mathematics, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
5
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
6
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
7
Division of Cancer, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway.
8
The Cancer Registry of Norway, Institute of Population-based Cancer Research, Oslo, Norway.
9
Department of Community Medicine, UIT The Artic University of Norway, Tromsø, Norway.
10
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
11
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Abstract

OBJECTIVE:

A number of observational studies have shown an inverse association between circulating 25-hydroxyvitamin D and total mortality, but a reverse J-shaped association has also been reported. In a large nested case-control study, serum-25-hydroxyvitamin D (s-25(OH)D) was positively associated with incident prostate cancer. Based on the same study population, the primary aim of the present study was to investigate the association between s-25(OH)D and total mortality.

METHODS:

Men participating in population based health screenings during 1981-1991 and enrolled in a nested case-control study were followed throughout 2007 with respect to all-cause and cause-specific mortality. Hazard ratios (HR) with 95% confidence intervals (CI) were calculated using Cox proportional hazards regression.

RESULTS:

In men with prostate cancer (n = 2282), there was a significant inverse association between s-25(OH)D and total mortality after controlling for potential confounders (HR = 1.25 (95% CI 1.05-1.50), s-25(OH)D <50 nmol/l versus s-25(OH)D ≥ 50 nmol/l). The corresponding figure among controls (n = 2147) was HR = 1.15 (95% CI 0.88-1.50) and in the total study population HR = 1.19 (95% CI 1.03-1.38). For cause-specific deaths, we found no significant associations.

CONCLUSIONS:

In this study population, s-25(OH)D was inversely associated with total mortality during more than two decades of follow-up, despite, as previous reported, high s-25(OH)D was associated with increased risk of prostate cancer.

PMID:
26986958
PMCID:
PMC4795600
DOI:
10.1371/journal.pone.0151441
[Indexed for MEDLINE]
Free PMC Article

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