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Curr Mol Biol Rep. 2016 Mar;2(1):1-9. Epub 2016 Feb 4.

Spatial Organization of Epigenomes.

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1
Department of Biochemistry and Goodman Cancer Research Center, McGill University, 3655 Promenade Sir-William-Osler, Room 815A, Montréal, Québec, Canada, H3G1Y6.

Abstract

The role of genome architecture in transcription regulation has become the focus of an increasing number of studies over the past decade. Chromatin organization can have a significant impact on gene expression by promoting or restricting the physical proximity between regulatory DNA elements. Given that any change in chromatin state has the potential to alter DNA folding and the proximity between control elements, the spatial organization of chromatin is inherently linked to its molecular composition. In this review, we explore how modulators of chromatin state and organization might keep gene expression in check. We discuss recent findings and present some of the less well-studied aspects of spatial genome organization such as chromatin dynamics and regulation by non-coding RNAs.

KEYWORDS:

Chromatin organization; Chromosome conformation capture; Epigenetics; Gene expression; Non-coding RNAs

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