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Cancer Invest. 2016;34(3):148-54. doi: 10.3109/07357907.2016.1139716. Epub 2016 Mar 17.

Does the Presence of Endometriosis Affect Prognosis of Ovarian Cancer?

Author information

1
a Division of Gynecologic Oncology, Weill Cornell Medical College , New York , NY , USA.
2
b Department of Pathology and Laboratory Medicine , Weill Cornell Medical College , New York , NY , USA.
3
c Weill Cornell Medical College , New York , NY , USA.
4
d Division of Gynecologic Oncology , New York , NY , USA.

Abstract

Ovarian cancers diagnosed between 2000 and 2013 were examined and cases with and without endometriosis compared. Among 139 epithelial ovarian, there were 49 (35%) with endometriosis and 90 (65%) without endometriosis. Endometriosis associated ovarian cancers were more likely to be confined to the pelvis (54% vs. 9%, p < 0.0001) and lower grade (51% vs. 29%, p = 0.014). Younger age and earlier stage independently predicted the presence of endometriosis (p = 0.0011 and p < 0.0001, respectively). Ovarian cancer patients with endometriosis had improved PFS and OS [(HR = 0.20; 95% CI, 0.09-0.43), (HR = 0.18; 95% CI, 0.04-0.81)], compared to patients without endometriosis; however, endometriosis had no independent prognostic significance.

KEYWORDS:

Epidemiology; Outcomes research; Outreach; Ovarian cancer

PMID:
26986692
PMCID:
PMC5292825
DOI:
10.3109/07357907.2016.1139716
[Indexed for MEDLINE]
Free PMC Article

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