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Biomarkers. 2016 Sep;21(6):479-89. doi: 10.3109/1354750X.2016.1153725. Epub 2016 Mar 17.

NMR- and GC/MS-based metabolomics of sulfur mustard exposed individuals: a pilot study.

Author information

1
a Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran ;
2
b Faculty of Paramedical Sciences, Department of Basic Sciences , Shahid Beheshti University of Medical Sciences , Tehran , Iran ;
3
c Pulmonary Department , Shariati Hospital, Tehran University of Medical Sciences , Tehran , Iran ;
4
d Department of Chemistry , Faculty of Paramedical Sciences, Tarbiat Modares University , Tehran , Iran ;
5
e Department of Chemistry , Sharif University of Technology , Tehran , Iran ;
6
f Department of Chemistry , Faculty of Science, University of Tehran , Tehran , Iran ;
7
g Chemistry and Chemical Engineering Research Center of Iran , Tehran , Iran.

Abstract

Sulfur mustard (SM) is a potent alkylating agent and its effects on cells and tissues are varied and complex. Due to limitations in the diagnostics of sulfur mustard exposed individuals (SMEIs) by noninvasive approaches, there is a great necessity to develop novel techniques and biomarkers for this condition. We present here the first nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC/MS) metabolic profiling of serum from and healthy controls to identify novel biomarkers in blood serum for better diagnostics. Of note, SMEIs were exposed to SM 30 years ago and that differences between two groups could still be found. Pathways in which differences between SMEIs and healthy controls are observed are related to lipid metabolism, ketogenesis, tricarboxylic acid (TCA) cycle and amino acid metabolism.

KEYWORDS:

Gas chromatography–mass spectrometry; human serum; metabolomics; nuclear magnetic resonance; sulfur mustard

PMID:
26984270
DOI:
10.3109/1354750X.2016.1153725
[Indexed for MEDLINE]

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