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Int J Food Sci Nutr. 2016 Jun;67(4):441-53. doi: 10.3109/09637486.2016.1161010. Epub 2016 Mar 17.

Efficacy of phytosterols and fish-oil supplemented high-oleic-sunflower oil rich diets in hypercholesterolemic growing rats.

Author information

1
a Department of Biochemistry, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina ;
2
b Pediatric Sunshine Academics Inc , Santa Barbara , CA , USA ;
3
c Department of Physiology, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina ;
4
d Department of General and Oral Biochemistry, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina.

Abstract

Phytosterols (P) and fish-oil (F) efficacy on high-oleic-sunflower oil (HOSO) diets were assessed in hypercholesterolemic growing rats. Controls (C) received a standard diet for 8 weeks; experimental rats were fed an atherogenic diet (AT) for 3 weeks, thereafter were divided into four groups fed for 5 weeks a monounsaturated fatty acid diet (MUFA) containing either: extra virgin olive oil (OO), HOSO or HOSO supplemented with P or F. The diets did not alter body weight or growth. HOSO-P and HOSO-F rats showed reduced total cholesterol (T-chol), non-high-density lipoprotein-cholesterol (non-HDL-chol) and triglycerides and increased HDL-chol levels, comparably to the OO rats. Total body fat (%) was similar among all rats; but HOSO-F showed the lowest intestinal, epididymal and perirenal fat. However, bone mineral content and density, and bone yield stress and modulus of elasticity were unchanged. Growing hypercholesterolemic rats fed HOSO with P or F improved serum lipids and fat distribution, but did not influence material bone quality.

KEYWORDS:

Body fat; bone quality; fish oil; high-oleic-sunflower oil; lipid profile; phytosterol; weight and growth gain

PMID:
26983467
DOI:
10.3109/09637486.2016.1161010
[Indexed for MEDLINE]

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