Format

Send to

Choose Destination
Immunity. 2016 Mar 15;44(3):476-491. doi: 10.1016/j.immuni.2016.02.014.

Molecular Determinants in Phagocyte-Bacteria Interactions.

Author information

1
Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany. Electronic address: kaufmann@mpiib-berlin.mpg.de.
2
Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany. Electronic address: dorhoi@mpiib-berlin.mpg.de.

Abstract

Phagocytes are crucial for host defense against bacterial pathogens. As first demonstrated by Metchnikoff, neutrophils and mononuclear phagocytes share the capacity to engulf, kill, and digest microbial invaders. Generally, neutrophils focus on extracellular, and mononuclear phagocytes on intracellular, pathogens. Reciprocally, extracellular pathogens often capitalize on hindering phagocytosis and killing of phagocytes, whereas intracellular bacteria frequently allow their engulfment and then block intracellular killing. As foreseen by Metchnikoff, phagocytes become highly versatile by acquiring diverse phenotypes, but still retaining some plasticity. Further, phagocytes engage in active crosstalk with parenchymal and immune cells to promote adjunctive reactions, including inflammation, tissue healing, and remodeling. This dynamic network allows the host to cope with different types of microbial invaders. Here we present an update of molecular and cellular mechanisms underlying phagocyte functions in antibacterial defense. We focus on four exemplary bacteria ranging from an opportunistic extracellular to a persistent intracellular pathogen.

PMID:
26982355
DOI:
10.1016/j.immuni.2016.02.014
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center