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Retrovirology. 2016 Mar 15;13:16. doi: 10.1186/s12977-016-0249-x.

Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis.

Author information

1
Laboratory of Virus Control, Institute for Virus Research, Kyoto University, Kyoto, Japan.
2
Laboratory of Virus Control, Institute for Virus Research, Kyoto University, Kyoto, Japan. mmatsuok@virus.kyoto-u.ac.jp.

Abstract

Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus responsible for the development of adult T-cell leukemia (ATL). Although HTLV-1 harbors an oncogene, tax, that transforms T cells in vitro and induces leukemia in transgenic mice, tax expression is frequently disrupted in ATL, making the oncogenesis of ATL a bit mysterious. The HTLV-1 bZIP factor (HBZ) gene was discovered in 2002 and has been found to promote T-cell proliferation and cause lymphoma in transgenic mice. Thus HBZ has become a novel hotspot of HTLV-1 research. This review summarizes the current findings on HBZ with a special focus on its potential links to the oncogenesis of ATL. We propose viewing HBZ as a critical contributing factor in ATL development.

KEYWORDS:

HBZ; HTLV-1; Regulatory T cell; Tax; Viral oncogenesis

PMID:
26979059
PMCID:
PMC4793531
DOI:
10.1186/s12977-016-0249-x
[Indexed for MEDLINE]
Free PMC Article

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