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J Immunol Res. 2016;2016:5371050. doi: 10.1155/2016/5371050. Epub 2016 Feb 10.

Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes.

Author information

1
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA.
2
Division of Epidemiology, University of California Berkeley, Berkeley, CA 94720, USA.
3
Department of Psychiatry, University of California San Francisco, San Francisco, CA 94118, USA.
4
School of Kinesiology, University of British Columbia, Vancouver, BC, Canada V6T 1Z1.
5
Core Immunology Lab, Division of Experimental Medicine, University of California San Francisco, San Francisco, CA 94110, USA.

Abstract

Telomeres, the protective DNA-protein complexes at the ends of linear chromosomes, are important for genome stability. Leukocyte or peripheral blood mononuclear cell (PBMC) telomere length is a potential biomarker for human aging that integrates genetic, environmental, and lifestyle factors and is associated with mortality and risks for major diseases. However, only a limited number of studies have examined longitudinal changes of telomere length and few have reported data on sorted circulating immune cells. We examined the average telomere length (TL) in CD4+, CD8+CD28+, and CD8+CD28- T cells, B cells, and PBMCs, cross-sectionally and longitudinally, in a cohort of premenopausal women. We report that TL changes over 18 months were correlated among these three T cell types within the same participant. Additionally, PBMC TL change was also correlated with those of all three T cell types, and B cells. The rate of shortening for B cells was significantly greater than for the three T cell types. CD8+CD28- cells, despite having the shortest TL, showed significantly more rapid attrition when compared to CD8+CD28+ T cells. These results suggest systematically coordinated, yet cell type-specific responses to factors and pathways contribute to telomere length regulation.

PMID:
26977417
PMCID:
PMC4764743
DOI:
10.1155/2016/5371050
[Indexed for MEDLINE]
Free PMC Article

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