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Biomed Opt Express. 2016 Jan 29;7(2):701-8. doi: 10.1364/BOE.7.000701. eCollection 2016 Feb 1.

Hollow optical-fiber based infrared spectroscopy for measurement of blood glucose level by using multi-reflection prism.

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Graduate School of Biomedical Engineering, Tohoku University, 6-6-05 Aoba, Sendai 980-8579, Japan.
Graduate School of Engineering,Tohoku University, 6-6-05 Aoba, Sendai 980-8579, Japan.


A mid-infrared attenuated total reflection (ATR) spectroscopy system employing hollow optical fibers and a trapezoidal multi-reflection ATR prism has been developed to measure blood glucose levels. Using a multi-reflection prism brought about higher sensitivity, and the flat and wide contact surface of the prism resulted in higher measurement reproducibility. An analysis of in vivo measurements of human inner lip mucosa revealed clear signatures of glucose in the difference spectra between ones taken during the fasting state and ones taken after ingestion of glucose solutions. A calibration plot based on the absorption peak at 1155 cm(-1) that originates from the pyranose ring structure of glucose gave measurement errors less than 20%.


(060.2390) Fiber optics, infrared; (170.3890) Medical optics instrumentation; (300.6300) Spectroscopy, Fourier transforms

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